Glucose-6-Phosphate Isomerase

An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.

Also Known As:

Phosphoglucose Isomerase; Glucose 6 Phosphate Isomerase; Glucosephosphate Isomerase; Autocrine Motility Factor; Isomerase, Glucose 6 Phosphate; Neuroleukin; Tumor Autocrine Motility Factor; Tumor-Cell Autocrine Motility Factor; Factor, Autocrine Motility; Isomerase, Glucose-6-Phosphate; Isomerase, Glucosephosphate; Isomerase, Phosphoglucose; Isomerase, Phosphohexose; Motility Factor, Autocrine; Tumor Cell Autocrine Motility Factor; Phosphohexose Isomerase; D-Glucose-6-phosphate ketol-isomerase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - Intramolecular Oxidoreductases
      - Aldose-Ketose Isomerases
        Glucose-6-Phosphate Isomerase: 489

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Disease

Drug/Important Bio-Agent (IBA)